David Sinclair’s Top Recommended Supplements: NMN & More

Fish Oil

Fish oil is loaded with beneficial omega-3 fatty acids, specifically EPA and DHA. It promotes cardiovascular health by lowering triglycerides and blood pressure. It also reduces inflammation throughout the body. Additionally, it may boost brain function. This makes it a vital addition to any longevity-focused regimen.

Sinclair did not specify his fish oil dosage. However, several longevity experts recommend it. Dr. Andrew Huberman and Dr. Peter Attia suggest taking 2 grams of EPA and about 1.5 grams of DHA.

L-Taurine (2 g)

Taurine is a crucial amino acid for heart health, muscle function, and metabolic processes. It’s linked to improved exercise performance and may also help counteract age-related declines in muscle mass and strength, making it especially beneficial as we age.

In a recent podcast, Sinclair shared his confusion about taurine’s effects. Some studies suggest it activates mTOR, often linked to accelerated aging. However, taurine also appears to promote longevity. He takes 2 g of taurine daily, although it remains uncertain whether he will continue this supplementation.

NMN (1 g)

Nicotinamide mononucleotide (NMN) is a critical precursory element to NAD+, which is vital for cellular energy generation and restoration processes. NMN is a fundamental part of Sinclair’s regimen. The David Sinclair NMN dosage can help boost NAD+ levels, which are crucial for cellular energy, DNA repair, and regulating aging.

NMN supplementation addresses the natural decline of NAD+ levels that happens with age. This promotes cellular health and has generated significant interest in anti-aging and wellness strategies.

Resveratrol (1 g)

Resveratrol is a highly potent antioxidant present in red wine. It activates sirtuin pathways linked to longevity and cellular health. Its anti-inflammatory properties support heart health and may boost metabolic function.

Each morning, Sinclair takes 1 g of resveratrol with coconut yogurt. This plant-based polyphenol is also found in blueberries and peanuts. It reduces oxidative stress and helps combat ‘inflammaging.’ This term describes inflammation’s role in age-related issues.

Spermidine (1-2 mg)

This compound occurs naturally and is mainly found in wheat germ, mushrooms, green peas, and broccoli. It promotes autophagy, the body’s way of eliminating damaged cells and regenerating new ones. Research shows that spermidine can extend lifespan in various organisms, including mice and worms, which highlights its potential as a longevity promoter. Its ability to activate autophagy helps repair and rejuvenate the body.

It also has protective effects on the heart. Additionally, it positively influences age-related diseases, such as cancer and neurodegeneration, in some animals. Therefore, there’s strong evidence that spermidine may enhance healthspan and longevity.

Vitamins D3 (4,000-5,000 IU) And K2 (180-360 mcg)

These vitamins work together to support vital bodily functions. Vitamin D3 is needed for bone health and supports immune function. Vitamin K2 plays an integral part in the metabolism of calcium. It ensures calcium is deposited in bones instead of soft tissues or arteries.

Together, they enhance skeletal strength and cardiovascular health. These are crucial for combating age-related decline.

Trimethylglycine (500 mg/day)

Trimethylglycine (TMG) is a compound produced by the body and found in beetroot. It’s essential for methylation processes, which are involved in DNA repair and detoxification. Sinclair takes TMG as a precaution, along with his NMN supplementation.

Elevated nicotinamide levels from NMN are excreted through the kidneys with attached methyl groups. These groups are vital for processes like DNA methylation that regulate gene expression. TMG helps maintain genetic integrity and promotes overall cellular health by supporting these processes.

Low-Dose Aspirin (83 mg)

Aspirin is widely recognized for its anti-inflammatory effects. Low-dose aspirin may enhance longevity by reducing chronic inflammation, a significant factor in age-related diseases. This could result in better overall health outcomes. Sinclair incorporates this into his regimen, highlighting its potential to lower cancer risk.

Metformin (1 g)

Metformin was initially developed as a diabetes medication. It has gained attention for its potential to extend lifespan. The drug improves metabolic health and enhances insulin sensitivity. Additionally, it reduces inflammation. Together, these effects may significantly promote longevity.

In an interview, Sinclair discusses his use of 1 g of Metformin. He mentions his family’s history of diabetes and the drug’s effectiveness in treatment and prevention. He highlights research showing that animals and tens of thousands of people in clinical trials benefit from Metformin. It appears to enhance the effects of fasting.

Rapamycin 

First discovered in a volcano on Easter Island (Rapa Nui), this drug targets the mTOR pathway, a key regulator of cell development and metabolism. Scientists have noted it as the last known longevity drug in Sinclair’s protocol. Research links mTOR inhibition to lifespan extension in various organisms, which highlights rapamycin’s potential as a powerful anti-aging intervention.

The exact dosage of rapamycin taken by Sinclair is unknown. However, longevity entrepreneur Dr. Peter Diamandis said in an interview that he takes 6 mg of rapamycin weekly.

Incorporating these supplements into a daily routine may support longevity and enhance overall well-being during the aging process.